Scandinavian Journal of Work, Environment & Health
İÇİNDEKİLERCONTENTSIntroduction General background PULMONARY EFFECTS AFTER EXPOSURE TO MANGANESE DIOXIDE Epidemiologic studies Experimental studies CONCLUSIONS AND COMMENTS SCOPE OF THE PRESENT INVESTIGATION Material and methods EXPERIMENTAL TECHNIQUES Animals Manganese dioxide aerosol Generation Particle size and dust concentration Exposure conditions Bacterial aerosol Exposure regimes Preparations and measurements Determination of manganese dioxide in the lung Number of free lung cells Determination of macrophages with phagocytized manganese dioxide particles Measurement of clearance of viable bacteria Histological evaluation of lung section TREATMENT OF DATA Results LUNG CLEARANCE OF MANGANESE DIOXIDE PARTICLES NUMBER OF MACROPHAGES NUMBER OF LEUKOCYTES PHAGOCYTOSIS OF MANGANESE DIOXIDE CLEARANCE OF VIABLE BACTERIA CHANGES IN LUNG TISSUE AFTER EXPOSURE TO MANGANESE DIOXIDE General discussion METHODS RESULTS Lung clearance Macrophages Leukocytes Clearance of viable bacteria Histology Conclusions Summary Acknowledgments References Appendix  |
