Asbestos Exposure of Finnish Mesothellioma Patients
İÇİNDEKİLERContentList of original publications............................................... Abbreviations................................................................... Introduction..................................................................... Review of the literature..................................................... Mineral fibers: definition, properties and health effects........... Terminology..................................................... Asbestos minerals............................................... Other natural fibrous minerals................................ Man-made mineral fibers...................................... Mesothelioma as a pathological entity................................ Association between mineral fibers and mesothelioma............. Mesothelioma and exposure to asbestos..................... Mesothelioma and exposure to other mineral fibers....... Experimental studies on fiber deposition, retention and carcinogenicity.................................................. Other causes of mesothelioma......................................... Assessment of past exposure to mineral fibers...................... Work history..................................................... Lung fiber analysis.............................................. Bronchoalveolar lavage........................................ Asbestos use and incidence of mesothelioma in Finland........... Aims of the study............................................................, Material and methods........................................................ Subjects................................................................... Mesothelioma patients........................................., Sarcoidosis patients............................................, Autopsy cases and office workers............................ Asbestos sprayers................................. Evaluation of work history................................ Bronchoalveolar lavage................................... Electron microscopy and X-ray microanalysis........ Sample preparation of lung samples........... Sample preparation ofBAL samples........... Fiber counting..................................... X-ray microanalysis............................... Counting of asbestos bodies with light microscopy... Statistical methods......................................... Results.............................................................. Exposure to asbestos as evaluated from work history Mineral fiber concentration in lung tissue.............. Mineral fiber types and fiber sizes...................... Relative risk of mesothelioma........................... Alveolar fiber load in asbestos sprayers................ Discussion......................................................... Assessment of past exposure from work history...... Fiber analysis from lung tissue and BAL fluid........ Lung fiber concentrations in different groups......... Fiber types.................................................. Alveolar fiber load........................................ Relative risk estimation................................... Conclusions....................................................... Acknowledgments.............................................. References......................................................... Original publications...........................................  |
