Encyclopaedia of Occupational Health And Safety I
İÇİNDEKİLERCONTENTSVOLUME 1 Preface to the Fourth Edition Prefaces to previous editions. . Foreword Authors and Editors PART 1.THE BODY 1. Blood Bernard D. Goldstein, Chapter Editor Haematopoietic and Lymphatic System ...................... Bernard D. Goldstein Leukaemia, Malignant Lymphomas............................. Timo Partanen, Paolo Boffetta, Elisabete Weiderpass and Multiple Miyalome Agents or Work Conditions Affecting the Blood............. Bernard D. Goldstein 2. Cancer Paolo Boffetta, Chapter Editor Introduction....................................... Mil Pearce, Paolo Boffetta and Manolis Kogevians Occupational Carcinogens Paolo Boffetta, Rodolfo Saracci, Manolis Kogevinas, Julian Wilbourn and Harri Vainio Environmental Cancer. .......................... Bruce K. Armstrong and Paolo Boffetta Prevention ............................................. Per Gustavsson 3. Cardiovascular System Lothar Heinemann and Gerd Heuchert, Chapter Editors Introduction............................................ Lothar Heinemann and Gerd Heuchert Cardiovascular Morbidity and Mortality in the Workforce .............................................................. Gottfried Enderlein and Lothar Heinemann The Risk Factor Concept in Cardiovascular Disease .................................................Lotthar Heinemann, Gottfried Enderlein and Hade Stark Rehabilitation and Prevention Programmes............. Lothar Heinemann and Gottfried Enderlein PHYSICAL CHEMICAL AND BIOLOGICAL HAZARDS Physical Factors ......................................... Heide Stark and Gerd Heuchert Chemical Hazardous Materias ..................... Ulrike Tittelbach and Wolfram Dietmar Schneider Biological Hazards........................................ Regina jackel, Ulrike Tittelbach and Wolfram Dietmar Schneider 4. Digestive System Heikki Savolainen, Chapter Editor Digestive System .......................................... G. Frada Mouth and Teeth............................................ K Gobbato Liver.............................................................. George Kazantzis Peptic Ulcer................................................... K.S. Cho Liver Cancer..................... Timo Partanen, Timo Kauppinen, Paolo Boffetta and Elisabete Weiderpass Pancreatic Cancer ............ Timo Partanen, Timo Kauppinen, Paolo Boffetta and Ellsabete Weiderpass NCYCLOPAEDIA OF OCCUPATIONAL HEALTH AND SAFETY CC CONTENTS 5. Mental Health Joseph J. Hurrell, Lawrence R. Murphy, Steven L. Sauter and Lennart Levi, Chapter Editors Work and Mental Healt.................. Irene L.D. Houtman and Michiel A.J. Kompier Work-related Psychosis ................ Craig Stenberg, Judith Holder and Krishna Tallur MOOD AND AFFECT Depression ............................... Jay Lasser and Jeffrey E Kahn Work-related Anxiety................. Randal D. Beaton Post-traumatic Stress Disorder and its Relationship to Occupational Health and Injury Prevention ........... Mark Braverman Stress and Burnout and their Implication in the Work Environment Herbert J. Ereudenberger Cognitive Disorders.................................. (Catherine A. Heaney Karoshi: Death from Overwork ................ Takashi Haralani 6. Musculoskcletal System Hilkka Riihimaki and Eira Viikari-Juntura, Chapter Editors Overview............................... Hilkka Riihimaki Muscles ................................... Gisela Sjugaard Tendons.................................... Thomas J. Armstrong Bones and Joints......................... David Hamerman Intervertebral Discs..................... Salty Roberts and Jill P G. Urban Low-back Region. Hilkka Riihimaki Thoracic Spine Region Jarl-Erik Michelsson Neck. Asa Kilbom Shoulder Mats Hagberg Elbow. Eira Viikan-Jimlura Forearm, Wrist and Hand Eira Viikari-Juntura Hip and Knee Eva Vingdrd Leg, Ankle and Foot Jarl-Erik Michelsson Other Diseases Marjatta Leirisalo-Repo 7. Nervous System Donna Mergler, Chapter Editor Nervous System: Overview Donna Mergler and Jose A, Valciukas Anatomy and Physiology. Jose A. Valdukas Chemical Neurotoxic Agents. Peter Arhen-S0borg and Leif Simonsen , Manifestations of Acute and Early Chronic Poisoning. Donna Mergler Preventing Neurotoxicity at Work Barry Johnson Clinical Syndromes Associated with Neurotoxieity Robert G. Eeldman Measuring Neurotoxicity Deficits Donna Mergler Diagnosis Anna Maria Seppalainen Occupational Neuroepidemiology Olav Axelson 8. Renal-Urinary System George P, Hemstreet, Chapter Editor Renal-Urinary Systems George K. Hemstreet Renal-Urinary Cancers Timo Partanen, Harri Vainio, Pa and Elisabete Weiderpass 9. Reproductive System Grace Kawas Lemasters, Chapter Editor Reproductive System; Introduction. Lowel E. Sever ENCYCLOPAEDIA OF OCCUPATIONAL HEALTH ANIntroduction to Male and Female Reproductive Function.............. Donald R. Mattison Male Reproductive System and Toxicology........... Steven Schrader and Grace Kawas Lemasters Structure of the Female Reproductive System and Target Organ Vulnerability ........................................................... Donald R. Matt?son Maternal Occupational Exposures and Adverse Pregnancy Outcomes..... Grace Kawas Lemasters Preterm Delivery and Work......................... NcoIe Mamelle Occupational and Environmental Exposures to the Newborn ................................................... Mary S. Wolff and Patrisha M, Woolard Maternity Protection in Legislation.......................... Marie-Clam Seguret Pregnancy and US Work Recommendations....... Leon J. Warskaw 10. Respiratory System Alois David and Gregory R. Wagner, Chapter Editors Structure and Function ..................................... Morion Lippmann Lung Function Examination ............................ UIf Ulfuarson and Monica Dahlqvist Diseases Caused by Respiratory Irritants and Toxic Chemicals ....................................................................... David L.S. Ryon and William M Ron Occupational Asthma ................................ George Friedman-Jimenez and Edward L. Pelsonk Diseases Caused by Organic Dusts ............. Ragnar Rylander and Richard S. E Schilling Beryllium Disease........................................ Homqyoun Kazemi Pneumoconioses: Definition ........................ Alois David ILO International Classification of Radiographs of Pneumoconioses...... Michel Lesage Aetiopathogenesis of Pneumoconioses................ Patrick Sebastien and Raymond Begin Silicosis....................................................... John E. Parker and Gregory R. Wagner Coal Workers' Lung Diseases ..................... Michael D. Attf?eld, Edward L. Petsonk and Gregory R. Wagner Asbestos-Related Diseases............................. Margaret R. Becklake Hard Metal Disease........................................Gerolamo Chiappino Respiratory System: The Variety of Pneumoconioses........ Steven R. Short and Edward L. Petsonk Chronic Obstructive Pulmonary Disease.............Kazimierz Marek and Jan E. Zejda Health Effects of Man-Made Fibres................... James E, Lockey and Clara S. Ross Respiratory Cancer ........................................... Paolo Boffetta and Elisabete Weiderpass Occupationally Acquired Infections of the Lung ...................................... Anthony A. Marf?n, Ann E Hubbs, Karl J. Musgrave, and John E. Parker 11. Sensory Systems Heikki Savolainen, Chapter Editor The Ear ................................... Marcel-Andre Boillat Chemically-Induced Hearing Disorders...............Peter Jacobsen Physically-Induced Hearing Disorders.................Peter L. Pelmear Equilibrium ..................................... Lucy Yardkey Vision and Work ............................ Paule Rey and Jean-Jacques Meyer Taste................................................. April E. Mott and Norman Mann Smell............................................. April E. Mott Cutaneous Receptors...................... Robert Dykes and Daniel McBain 12. Skin Diseases Louis-Philippe Durocher, Chapter Editor Overview: Occupational Skin Diseases.............. Donald J. Birmingham Non-Melanocytic Skin Cancer .................... Elisabete Weiderpass, Timo Partanen, Paolo Boffelta Malignant Melanoma .................................. Timo Partanen, Paolo Boffetta, Elisabete Weiderpass Occupational Contact Dermatitis ....................... Denis Sassevilk Prevention of Occupational Dermatoses.............. Louis-Philippe Durocher Occupational Nail Dystrophy.......................... C.D. Calnan Stigmata...................................................... H, Mierzcki 13. Systemic Conditions Howard M. Kipen, Chapter Editor Systemic Conditions: An Introduction............... Howard M. Kipen Sick Building Syndrome................................... Michael J. Hodgson Multiple Chemical Sensitivities.......................... Mark R. Cullen PART II. HEALTH CARE 14. First Aid and Emergency Medical Services Antonio J. Dajer, Chapter Editor First Aid ...................................... Antonio J. Dajer Traumatic Head Injuries................................ Fengsheng He 15. Health Protection and Promotion Jacqueline Messite and Leon J. Warshaw, Chapter Editors Health Protection and Promotion in the Workplace: An Overview ................................................ Leon J. Warshaw and Jacqueline Messite Worksite Health Promotion................................ Jonathan E. Fielding Health Promotion in the Workplace: England ............... Leon Kreitzman Health Promotion in Small Organizations: The US experience .......................... Sonia Muchnick-Baku and Leon J. Warshaw Role of the Employee Health Service in Preventive Programmes......... John W.E. Cowell Health Improvement Programmes at Maclaren Industries, Inc.: ACase Study.........lan M.F. Arnold and Lauis Damphousse Role of the Employee Health Service in Prevention Programmes: A Case Study......................................... Wayne N Burton Worksite Health Promotion in Japan...................... Toshiteru Okubo Health Risk Appraisal.............................. LeonJ. Warshaw Physical Training and Fitness Programmes: An Organizational Asset........ James Cony Worksite Nutrition Programmes .................... Penny M. Kris-Etherton and John W. Farquhar Smoking Control in the Workplace................... Jon Rudnick Smoking Control Programmes at Merrill Lynch and Company, Inc.: ACase Study. ...................................................Kristan D. Gold/ein Cancer Prevention and Control .......................... Peter Greenwald and Leon J. Warshaw Women's Health ............................................... Patricia A. Last Mammography Programme at Marks and Spencer: A Case Study........ Jillian Haslehurst Worksite Strategies to Improve Maternal and Infant Health: Experiences of US Employers............ Maureen P. Corry and Ellen Cutler HlV/AlDS Education ....................................... B.J. Stiles Health Protection and Promotion: Infectious Diseases..........William J. Schneider Protecting the Health of the Traveller.................. Craig Karpilow Stress Management Programmes........................ Leon J. Warshaw Alcohol and Drug Abuse................................... Sheila B. Blume Employee Assistance Programmes.................... Sheila H. Akabas Health in the Third Age: Pre-retirement Programmes. ........... H, Beric Wright Outplacement ....................... Saul G. Gruner and LeonJ. Warshaw 16. Occupational Health Services lgor A. Fedotov, Marianne Saux and Jorma Rantanen, Chapter Editors Standards, Principles and Approaches in Occupational Health Services................. Jorma Rantanen and Igor A. Fedotov Occupational Health Services and Practice .......... Georges H. Coppee Medical Inspection of Workplaces and Workers in France................ Marianne Saux Occupational Health Services in Small-Scale Enterprises..... Jorma Rantanen and Leon J. Warshaw Accident Insurance and Occupational Health Services in Germany................................... Wilfried Coenen and Edith Perlebach Occupational Health Services in the United States: Introduction . . Sharon L. Morris and Peter Orris Governmental Occupational Health Agencies in the United States........................ Sharon L, Morris and Linda Rosenstock Corporate Occupational Health Services in the United States: Services Provided Internally.................. William B. Bunn and Robert.J. Mccunney Contract Occupational Health Services in the United States.......... Penny Higgins Labour Union-Based Activities in the United States....................... laniard Byrd Academic-Based Occupational Health Services in the United States ........ Dean B. Baker Occupational Health Services in Japan.............. Km Takahashi Labour Protection in the Russian Federation: Law and Practice...................................Nikolai E. Izmerov and Igor A. Fedotov The Practice of Occupational Health Service in the People's Republic of China........ Zhi Su Occupational Safety and Health in the Czech Republic..... Vladimir Bencko and Daniela Pelclovd Practising Occupational Health in India................. T. K. Joshi .MANAGEMENT AND POLICY 17. Disability and Work Willi Momm and Robert Ransom, Chapter Editors Disability: Concepts and Definitions................... Willi Momm and Otto Geiecker Case Study: Legal Classification of Disabled People in France............................... Marie Louise Cros-Courtial and Marc Vericel Social Policy and Human Rights: Concepts of Disability ........... Carl Raskin International Labour Standards and National Employment Legislation in Favour of Disabled Persons........... Willi Momm and Masaaki luchi Vocational Rehabilitation and Employment Support Services.............. Erwin Seyfried Disability Management at the Workplace: Overview and Future Trends............................. Donald E. Shrey Rehabilitation and Noise-induced Hearing Loss....... Raymond Hetu Rights and Duties: An Employer's Perspective........ Susan Scott-Parker Rights and Duties: Workers' Perspective............ Angela Traiforos and Debra A. Perry 18. Education and Training Steven Hecker, Chapter Editor Introduction and Overview.............................. Steven Hecker Principles of Training....................................... Gordon Atherley and Dilys Robertson Worker Education and Training........................ Robin Baker and.Nina Wallerstein CASE STUDIES Evaluating Health and Safety Training: A Case Study in Chemical Workers Hazardous Waste Worker Education ......Thomas H. McQuiston, Paula Coleman, Nina Wallerstein, A.C. Marcus,J.S. Morawetz, David W. Ortlieb and Steven Hecker Environmental Education and Training: The State of Hazardous Materials Worker Education in the United States................. Glenn Paulson, Michelle Madelien, Susan Sink and Steven Hecker Worker Education and Environmental Improvement........... Edward Cohen-Rosenlhal Safety and Health Training of Managers.............................. John Rutdge Training of Health and Safety Professionals.......................... Wai-On Phoon A New Approach to Learning and Training: A Case Study by the ILO-FINNIDA African Safety and Health Project............................... Antero Vahapassi and Mem Weinger 19. Ethical Issues Georges H. Coppee, Chapter Editor Codes and Guidelines .................... Colin L. Soskolne Responsible Science: Ethical Standards and Moral Behaviour in Occupational Health....... Richard A. Lemen and Phillip W String Ethical Issues in Occupational Health And Safety Research......................... Paul W. Rrandt-Rauf and Sherry 1. Brandt-Rauf Ethics in the Workplace: A Framework for Moral Judgement........... Sheldon W Samuels Surveillance of the Working Environment........... Lawrence D. Kornreich Ethical Issues: Information and Confidentiality...... Peter J. M. Westerholm Ethics in Health Protection and Health Promotion.... D. Wayne Cornell and Annalee Yassi Case Study: Drugs and Alcohol in the Workplace--Ethical Considerations ............. Behrouz Shahandeh and Robert Husbands International Code of Ethics for Occupational Health Professionals ......................... International Commission on Occupational Health 20. Development, Technology and Trade Jerry Jeyaratnam, Chapter Editor Occupational Health Trends in Development ........ Jerry Jeyaratnam Industrialized Countries and Occupational Health and Safety .............. Toshiteru Okubo Case Studies in Technological Change................ Michael J. Wrighl Small Enterprises and Occupational Health and Safety................. Bill Glass Transfer of Technology and Technological Choice..................... Joseph LaDou Free-Trade Agreements...................................... Howard Frumkin Product Stewardship and the Migration of Industrial Hazards......... Barry Castleman Economic Aspects of Occupational Health and Safety..................... Alan Maynard Case Study: Industrialization and Occupational Health Problems in China. ........ Zhi Su 21. Labour Relations and Human Resources Management Anne Trebilcock, Chapter Editor Labour Relations and Human Resources Management: An Overview........ Anne Trebilcock Rights of Association and Representation............................... Breen Creighlon Collective Bargaining and Safety and Health........................... Michael J. Wright National Level Tripartite and Bipartite Cooperation on Health and Safety........................................... Robert Husbands Forms of Workers' Participation .............Muneto Ozaki and Anne Trebilcock Consultation and lnformation on Health and Safety................. Marco Biagi Labour Relations Aspccts of Training........................ Mel Doyle Labour Rclations Aspects of Labour Inspection ............... Maria Luz Vega Ruiz Collective Disputes over Health and Safety Issues............... Shauna L. Olney Individual Disputes over Health and Safety Issues.............. Amu Trebilcock22. Resources: Information and OSH Jukka Takala, Chapter Editor Information: A Precondition for Action.......................... Jukka Takala Finding and Using Information. . . PK. Abeytunga,Emmert Clevenstine, Vivian Morgan and Sheila Pantry Information Management............................................. Gordon Atherley Case Study: Malaysian Information Service on Pesticide Toxicity.......................... DA. Razak, A.A. Latiff, M.1A. Majid and R. Awang Case Study: A Successful Information Experience in Thailand..............Chaiyuth Chavalitnitikul 23. Resources, Institutional, Structural and Legal Rachael F. Taylor and Simon Pickvance, Chapter Editors Institutional, Structural and Legal Resources: Introduction................ Simon Pickvance Labour Inspection ............................... Wolfgang von Richthofen Civil and Criminal Liability in Relation to Occupational Safety and Health.................... Felice Morgenstern (adapted) Occupational Health as a Human Right .............Rise Lay Feitshans COMMUNITY LEVEL Community-Based Organizations...................... Simon Pickvance Right to Know: The Role of Community-Based Organizations........Carolyn Needleman The COSH Movement and Right to Know......... Joel Shufro REGIONAL AND NATIONAL EXAMPLES Occupational Health and Safety: The European Union............. Frank B. Wright Legislation Guaranteeing Benefits for Workers in China..............Zhi Su Case Study: Exposure Standards in Russia ............ Nikolai F. Izmerov INTERNATIONAL GOVERNMENTAL AND NON-GOVERNMENTAL ORGANIZATIONS International Cooperation in Occupational Health: The Role of International Organizations.............. Georges H. Coppee International Labour Organization..................... Georg R. Kliesch ILO Conventions--Enforcement Procedures ........ Anne Trebilcock International Organization for Standardization (ISO)............ Lawrence D. Eicher International Social Security Association (ISSA).................. Dick J. Meertens International Commission on Occupational Health (ICOH).......... Jerry Jeyaratnam International Association of Labour Inspection (IALI) ............ David Snowball 24. Work and Workers Jeanne Mager Stellman and Leon J. Warshaw, Chapter Editors Work and Workers................................ Freda L. Paltiel Shifting Paradigms and Policies..................Freda L. Paltiel Health, Safety and Equity in the Workplace.............. Joan Bertin Precarious Employment and Child Labour............ lron J. Warshaw Transformations in Markets and Labour ............... Pal Armstrong Globalizing Technologies and the Decimation/Transformation of Work..... Heather Menzies 25. Workers' Compensation Systems Terence G. Ison, Chapter Editor Overview ...................................... Terence G. Ison PART ONE: WORKERS' COMPENSATION Coverage Organization, Administration and Adjudication. Eligibility for Benefits. Multiple Causes of Disability Subsequent Consequential Disabilities Compensable Losses Multiple Disabilities. Objections to Claims Employer Misconduct Medical Aid. . Money Payments Rehabilitation and Care Obligations to Continue the Employment Finance Vicarious Liability Health and Safety Claims against Third Parties Social Insurance and Social Security PART TWO: OTHER SYSTEMS Accident Compensation Sick Pay Disability Insurance Employers' Liability. 26. Workers' Compensation Systems, Topics In Paule Rey and Michel Lesage, Chapter Editors Work-related Diseases and Occupational Diseases: The ILO International List..... Michel Lesage Workers' Compensation: Trends and Perspectives...................... Paule Rey Prevention, Rehabilitation and Compensation in the German Accident Insurance System.................... Dieter Greiner andAndreas Kranig Employment Injuries Insurance and Compensation in Israel......... Haim Chayon Workers' Accident Compensation in Japan ......... Kazutaka Kogi and Haruko Suzuki Country Case Study: Sweden.............................. Peter Westerholm PART IV. TOOLS AND APPROACHES 27. Biological Monitoring Robert Lauwerys, Chapter Editor General Principles........................................ Vito Foa and Lorenzo Ales.sio Quality Assurance......................................... David Gompertz Metals and Organometallic Compounds ........ Perrine Hoet and Robert Lauwerys Organic Solvents .......................................... Masayuki ?lkeda Genotoxic Chemicals...................................... Marja Sona Pesticides....................................................... Marco Maroni andAdalberto Ferioli28. Epidemiology and Statistics Franco Merletti, Colin L. Soskolne and Paolo Vineis, Chapter Editors Epidemiological Method Applied to Occupational Health and Safety......... Franco Merletti, Colin L. Soskolne and Paolo Vineis Summary Worklife Exposure Measures............... Colin L. Soskolne Measuring Effects of Exposures........................... Shelia Hoar Zahm , Options in Study Design................................ Sven Hernberg Validity Issues in Study Design ............................ Annie Z. Sasco Impact of Random Measurement Error................ Paolo Vineis and Colin L. Soskolne Statistical Methods.............................................. Annibale Biggeri and Mario Braga Causality Assessment and Ethics in Epidemiological Research......... Paolo Vineis Case Studies Illustrating Methodological Issues in the Surveillance of Occupational Diseases.................................... Jung-Der Wang Questionnaires in Epidemiological Research......... Steven D. Stellman and Colin L. Soskolne Asbestos: Historical Perspective...........................Lawrence Garf?nkel 29. Ergonomics Wolf gang Laurig and Joachim Vedder, Chapter Editors Overview ...................................................... Wolfgang Laurig and Joachim Vedder GOALS, PRINCIPLES AND METHODS The Nature and Aims of Ergonomics............... William T. Singleton Analysis of Activities, Tasks and Work Systems.... Veronique De Keyser Ergonomics and Standardization...................... Friedhelm Nachreiner Checklists ..................................................... Pranab Kumar.Nag PHYSICAL AND PHYSIOLOGICAL ASPECTS Anthropometry............................................... Melchiorre Masali Muscular Work.............................................. Juhani Smolander and Veikko Louhevaara Postures at Work........................................... llkka Kuorinka Biomechanics................................................. Frank Darby General Fatigue.............................................. Etienne Grandjean Fatigue and Recovery.................................... Rolf Helbig and Walter Rohmert PSYCHOLOGICAL ASPECTS Mental Workload...........................................Winftied Hacker Vigilance........................................................Herbert Heuer Mental Fatigue.............................................. Peter Richter ORGANIZATIONAL ASPECTS OF WORK Work Organization....................................... Eberhard Ulich and Gudela Grole Sleep Deprivation..........................................Kazutaka Kogi WORK SYSTEMS DESIGN Workstations................................................ Roland Kadefors Tools........................................................... T.M. Fraser Controls, Indicators and Panels..................... Karl H. E. Kroemer Information Processing and Design................. Andries F. Sanders DESIGNING FOR EVERYONE Designing for Specific Groups....................... Joke H. Grady-van den Nieuwboer Cultural Differences....................................... Houshang Shahnavaz Elderly Workers...........................................Antoine Laville and Serge Volkoff Workers with Special Needs ........................ Joke H. Grady-van den Nieuze'boer DIVERSITY AND IMPORTANCE OF ERGONOMICS- TWO EXAMPLES System Design in Diamond Manufacturing ........ Issachar Gilad Disregarding Ergonomic Design Principles: ChernobyI......... Vladimir M. Munipov 30. Occupational Hygiene Robert F. Herrick, Chapter Editor Goals, Definitions and General Information............ Berenice I. Ferrari Goelzer Recognition of Hazards .........................................Linnea Lillilienberg Evaluation of the Work Environment...................... Lori A. Todd Occupational Hygiene: Control of Exposures Through Intervention...... James Stezeaart The Biological Basis for Exposure Assessment.........Dick Heederik Occupational Exposure Limits................................. Dennis J. Paustenbach 31. Personal Protection Robert F. Herrick, Chapter Editor Overview and Philosophy of Personal Protection......Robert F. Herrick Eye and Face Protectors..................................... Kikuzi Kimura Foot and Leg Protection .................................... Toyohiko Miura Head Protection................................................. lsabelle Baity and Alain Maver Hearing Protection.............................................. John R. Franks and Elliott H. Berger Protective Clothing.............................................. S. Zack Mansdorf Respiratory Protection.......................................... Thomas J. Nelson 32. Record Systems and Surveillance Steven D. Stellman, Chapter Editor Occupational Disease Surveillance and Reporting Systems...... Steven B. Markowitz Occupational Hazard Surveillance.......................... David H. Wegman and Steven D. Stellman Surveillance in Developing Countries.......................David Koh and Kee-Seng Chia Development and Application of an Occupational Injury and Illness Classification System........................... Elyce Riddle Risk Analysis of Non-fatal Workplace Injuries and Illnesses ....... John W,Ruser Case Study: Worker Protection and Statistics on Accidents and Occupational Diseases-HVBG, Germany............. Martin Butz. and Burkhard Hqffmann Case Study: Wismut-A Uranium Exposure Revisited...... Heinz Otten and Horst Schulz Measurement Strategies and Techniques for Occupational Exposure Assessment in Epidemiology................. Frank Bochmann and Helmut Blome Case Study: Occupational Health Surveys in China ............. Zhi Su 33. Toxicology Ellen K. Silbergeld, Chapter Editor Introduction..................................................... Ellen K. Silbergeld GENERAL PRINCIPLES OF TOXICOLOGY Definitions and Concepts................................. Bo Holmberg, Johan Hb'gberg and Gunnar Johanson Toxicokinetics................................................. Dusan Djuruit Target Organ and Critical Effects..................... Marek JakubowskiEffects of Age, Sex and Other Factors..... Spomenka Tdisman Genetic Determinants of Toxic Response... Daniel W.Xebert and Ross A. McKinnon MECHANISMS OF TOXICITY Introduction and Concepts .......... Philip (G. Watanabe Cellular Injury and Cellular Death... Benjamin E Trump and Irene K. Berezesky Genetic, Toxicology .........................R. Rita Misra and Michael. P Waalkes Immunotoxicology........................... Joseph G. Vos and Henk van loveren Target Organ Toxicology................ Ellen A! Silbergeld TOXICOLOGY TEST METHODS Biomarkers....................................... Philippe. Grandjean Genetic Toxicity Assessment............... David M, DeManni and James E. Huff In Vitro Toxicity Testing......................... Joanne Zurlo Structure Activity Relationships............ Ellen K. Silbergeld REGULATORY TOXICOLOGY Toxicology in Health and Safety Regulation....... Ellen K. Silbergeld Principles of Hazard Identification:The Japanese Approach..... Masayuki Ikeda The United States Approach to Risk Assessment of Reproductive Toxicants and Ncurotoxic Agents .......................................... Ellen K. Silbergeld Approaches to Hazard Identification: lARC............ Ham Vainio and Julian Wilbourn Appendix: Overall Evaluations of Carcinogenicity to Humans: IARC Monographs Volumes 1-69 (836) Carcinogen Risk Assessment: Other Approaches........ Cees A. van der Heyjden VOLUME Authors and Editors NOTLARfourth edition |
